The hero ingredient is exosomes, and you use it as a targeted treatment step. With an excellent 4.6 out of 5 from over 5k ratings, it is one of the best-reviewed pdrn & salmon dna in the range. It uses active ingredients, so patch test first and introduce it slowly if your skin is reactive.
Pros
Excellent 4.6/5 rating from 5k shoppers
Built around exosomes, a genuinely on-trend active
Cons
Contains actives that can irritate reactive skin, so patch test first
Priced above the cheapest options in the range
As a food-and-cosmetic product, results vary from person to person
At a glance
Type
PDRN & Salmon DNA
Key ingredient
exosomes
Format
concentrated serum
Size
1.01 fl.oz
Routine step
Treatment (serum step)
Best for skin type
Oily, Dry, Sensitive, Combination, Normal
Sensitive-skin friendly
Use with care, contains actives
Rating
4.6 / 5 from 5,437 ratings
What buyers actually say
We read a sample of the Amazon reviews for this product and describe the pattern in our own words. It is a sample, not a survey of all 5,437 ratings, and we do not reproduce customer reviews.
The spicule format defines this sample of eleven reviews. Nearly everyone describes a prickling or pins-and-needles sensation during application, and opinions divide on whether that is tolerable or unpleasant, though most rate it highly regardless. The recurring praise is immediate smoothness, refined-looking pores, and a better surface for makeup. The more careful reviewers treat it as an occasional step rather than a daily one, spacing it out and noting that clean hands and clean skin matter. Temporary flushing is mentioned. This is not a low-effort product, and the sample suggests buyers who ignore the usage guidance are the ones most likely to have a bad time.
Praised for
Noticeably smoother skin surface right away
Pores look more refined over time
Works well as a makeup base
Pairs well with the brand's other steps
Criticised for
Prickling or stinging sensation on application
Temporary redness or flushed look after use
Needs careful spacing rather than daily use
Demands clean hands and skin to avoid problems
How the ratings break down
Amazon's own star distribution for this product, read on 2026-08-02. We show the one-star share too, because an average alone hides it.
5 star79%
4 star10%
3 star5%
2 star2%
1 star4%
What is exosomes?
Exosomes are cell-signaling particles used in skincare to support a more intensive, treatment-style boost to skin recovery and glow.
Ingredients as listed on Amazon
Copied from the Amazon listing on 2026-08-02. We have not verified this against the physical pack, and formulations change by market and batch. If an ingredient matters to you, check the pack itself.
Watch: medicube Exosome Shot Zero 7,500 PPM Spicule in action
medicube Exosome Shot Zero 7,500 PPM Spicule review · loaded from YouTube when you press play
Key features
Viral product beloved by everyone - Transform your skin with the Exosome + Shot Booster.
Exosome-Coated Technology - Harness the next-generation skincare with Exosome-coated Spicule and Exosome, p…
Superior Absorption & Hydration - Achieve unmatched hydration and absorption rates with our formula, which…
Clinically Proven & Gentle on Skin - Enjoy peace of mind with our clinically validated Tingling Ampoule tha…
Easy to Integrate into Skincare Routine - Apply our Tingling Ampoule easily with a three-step routine, star…
Frequently asked questions
Is the medicube Exosome Shot Zero 7,500 PPM Spicule good for sensitive skin?
It contains active ingredients, so it can be too much for very reactive skin. Patch test first, introduce it slowly, and skip it if your barrier is compromised.
How do you use the medicube Exosome Shot Zero 7,500 PPM Spicule?
Use it after toner, before moisturizer. Follow the directions on the pack, and always finish your morning routine with sunscreen.
Is the medicube Exosome Shot Zero 7,500 PPM Spicule worth it?
For the price, it is an easy recommendation: 4.6 out of 5 from a large number of shoppers, doing a clear job in the routine. Results vary from person to person, so manage expectations.
