Overview
The hero ingredient is salmon DNA PDRN, and you use it as a targeted treatment step. With a strong 4.5 out of 5 from 1k ratings, it is a well-liked pick. It is one of the gentler options in the range, so it suits most skin types including sensitive skin.
Pros
- Excellent 4.5/5 rating from 1k shoppers
- Built around salmon DNA PDRN, a genuinely on-trend active
- Gentle enough for daily use on most skin types
Cons
- Priced above the cheapest options in the range
- As a food-and-cosmetic product, results vary from person to person
At a glance
| Type | PDRN & Salmon DNA |
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| Key ingredient | salmon DNA PDRN |
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| Format | mask |
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| Size | 0.35 oz |
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| Routine step | Treatment (serum step) |
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| Best for skin type | Sensitive, Combination, Normal |
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| Sensitive-skin friendly | Yes, one of the gentler picks |
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| Rating | 4.5 / 5 from 1,105 ratings |
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What buyers actually say
We read a sample of the Amazon reviews for this product and describe the pattern in our own words. It is a sample, not a survey of all 1,105 ratings, and we do not reproduce customer reviews.
Reviewers in our sample overwhelmingly judge this by how their lips feel the next morning, and the recurring report is genuinely softer, less flaky lips rather than a glossy coating. The texture is described as thick but cushioning, and people say it stays on through the night and works for daytime use too. Scent and taste split the room. Several praise a soft rose or fruity smell, one long-term user tolerates a taste she dislikes because she is asleep, and a one-star reviewer threw it out over the artificial smell. One reviewer also warns the tint transfers to pillowcases.
Praised for
- Lips feel softer and less flaky by morning
- Thick, cushioning texture that is not sticky
- Stays put through the night
- Doubles as a daytime balm
Criticised for
- Scent and taste divide reviewers sharply
- One reviewer found it too artificial to keep
- Tint can transfer to pillowcases
- One reviewer found it gone by morning
How the ratings break down
Amazon's own star distribution for this product, read on 2026-08-02. We show the one-star share too, because an average alone hides it.
5 star 77%
4 star 9%
3 star 8%
2 star 2%
1 star 4%
What is salmon DNA PDRN?
PDRN (polydeoxyribonucleotide) is a soothing, skin-conditioning ingredient derived from salmon DNA, used to support the barrier and give a plumper, glowier look.
Ingredients as listed on Amazon
Copied from the Amazon listing on 2026-08-02. We have not verified this against the physical pack, and formulations change by market and batch. If an ingredient matters to you, check the pack itself.
Show the ingredient list
Diisostearyl Malate,Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate,Polyisobutene,Butyrospermum Parkii (Shea) Butter,Hydrogenated Polydecene,Microcrystalline Wax,Dipropylene Glycol,Glycerin,Water,Hydrogenated Lecithin,Polyglyceryl-10 Oleate,Adenosine,Cerresin,Titanium Dioxide,Caprylic/Capric Triglyceride,Polyhydroxystearic Acid,Alumina,Stearic Acid,Bisabolol,Silica Dimethyl Silylate,Lauryl Polyglyceryl-3 Polydimethylsiloxethyl Dimethicone,Lauryl Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone,Aluminum Hydroxide,D&C Red No. 30,Manganese Violet,FD&C Blue No. 1,Camellia Japonica Seed Oil,Sodium DNA,Tocopherol,Water,Butylene Glycol,Glycerin,1,2-Hexanediol,Hydrolyzed Collagen,Water,1,2-Hexanediol,Glycerin,Akebia Quinata Extract,Butylene Glycol,Caprylyl/Capryl Glucoside,Camellia Japonica Flower Extract,Polyglyceryl-10 Laurate,Polyglyceryl-10 Oleate,Propanediol,Acetyl Hexapeptide-8,Acetyl Tetrapeptide-5,Adenosine,Carnosine,Palmitoyl Tetrapeptide-7,Palmitoyl Tripeptide-5,Yeast Beta-Glucan.
Key features
- Long-lasting Moisture
- A Non-Sticky Lip Sleeping Mask.
- Candy Glow Lock-in Moisture
- Gentle for All
Frequently asked questions
Is the medicube PDRN Lip Sleeping Mask - Overnight good for sensitive skin?
Yes, it is one of the gentler options in the range and suits most skin types, including sensitive skin. As always, patch test first.
How do you use the medicube PDRN Lip Sleeping Mask - Overnight?
Use it after toner, before moisturizer. Follow the directions on the pack, and always finish your morning routine with sunscreen.
Is the medicube PDRN Lip Sleeping Mask - Overnight worth it?
For the price, it is an easy recommendation: 4.5 out of 5 from a large number of shoppers, doing a clear job in the routine. Results vary from person to person, so manage expectations.
Check price on Amazon →
