Overview
The hero ingredient is salmon DNA PDRN, and you use it as your daily moisturizer. With an excellent 4.6 out of 5 from over 2k ratings, it is one of the best-reviewed pdrn & salmon dna in the range. It is one of the gentler options in the range, so it suits most skin types including sensitive skin.
Pros
- Excellent 4.6/5 rating from 2k shoppers
- Built around salmon DNA PDRN, a genuinely on-trend active
- Gentle enough for daily use on most skin types
- Lightweight texture that layers cleanly under other products
Cons
- Priced above the cheapest options in the range
- As a food-and-cosmetic product, results vary from person to person
At a glance
| Type | PDRN & Salmon DNA |
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| Key ingredient | salmon DNA PDRN |
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| Format | moisturizer |
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| Size | 1.69 fl. oz |
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| Routine step | Moisturizer |
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| Best for skin type | Oily, Dry, Sensitive, Combination, Normal |
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| Sensitive-skin friendly | Yes, one of the gentler picks |
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| Rating | 4.6 / 5 from 2,208 ratings |
What buyers actually say
We read a sample of the Amazon reviews for this product and describe the pattern in our own words. It is a sample, not a survey of all 2,208 ratings, and we do not reproduce customer reviews.
The repeat theme in our sample is that this behaves lighter than the word cream implies. Reviewers describe a gel-cream that disappears quickly, leaves a glow rather than grease and sits under makeup without pilling, and several are on their second or third tube. Reports of plumper, smoother-looking skin arrive anywhere from a few days to a couple of weeks. Criticism is mild at about 3 percent one-star: one expected a richer texture and noticed slight tack afterward, another finds fragrance across the brand too strong to layer, and the tube strikes some as small.
Praised for
- Gel-cream texture absorbs fast and does not feel greasy
- Layers under sunscreen and makeup without pilling
- Skin described as plumper and smoother within days to weeks
- A little goes a long way, so the tube lasts longer than it looks
Criticised for
- Lighter than the rich cream some buyers expected
- Fragrance is too strong for one reviewer to layer with other products
- Slight stickiness reported before it fully sets
- Tube looks small for the price
How the ratings break down
Amazon's own star distribution for this product, read on 2026-08-02. We show the one-star share too, because an average alone hides it.
5 star 82%
4 star 9%
3 star 4%
2 star 2%
1 star 3%
What is salmon DNA PDRN?
PDRN (polydeoxyribonucleotide) is a soothing, skin-conditioning ingredient derived from salmon DNA, used to support the barrier and give a plumper, glowier look.
Ingredients as listed on Amazon
Copied from the Amazon listing on 2026-08-02. We have not verified this against the physical pack, and formulations change by market and batch. If an ingredient matters to you, check the pack itself.
Show the ingredient list
WATER, GLYCERETH-26, BUTYLENE GLYCOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, CYCLOPENTASILOXANE, 1,2-HEXANEDIOL, NIACINAMIDE, HYDROGENATED POLYDECENE, ISONONYL ISONONANOATE, CETEARYL OLIVATE, ETHYLHEXYL OLIVATE, GLYCERIN, SORBITAN OLIVATE, SODIUM DNA(5,000PPM), SODIUM ACRYLATES COPOLYMER, SODIUM POLYACRYLOYLDIMETHYL TAURATE, HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, POLYGLYCERYL-4 OLEATE, DISODIUM EDTA, BETAINE, PANTHENOL, FRAGRANCE, ETHYLHEXYLGLYCERIN, ADENOSINE, SORBITAN ISOSTEARATE, LIMNANTHES ALBA (MEADOWFOAM) SEED OIL, GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER, CITRIC ACID, CYANOCOBALAMIN, HYDROGENATED LECITHIN, CETEARYL ALCOHOL, STEARIC ACID, SODIUM HYALURONATE(1.02PPM), HYDROXYPROPYLTRIMONIUM HYALURONATE(0.1PPM), CERAMIDE NP, PRUNELLA VULGARIS EXTRACT, FUCUS VESICULOSUS EXTRACT, MORINDA CITRIFOLIA FRUIT EXTRACT, MOMORDICA CHARANTIA FRUIT EXTRACT, HIBISCUS ESCULENTUS FRUIT EXTRACT, CERAMIDE NS, SODIUM ACETYLATED HYALURONATE(0.01PPM), HYDROLYZED HYALURONIC ACID(0.01PPM), CENTELLA ASIATICA LEAF EXTRACT, CHOLESTEROL, PHYTOSPHINGOSINE, CERAMIDE AS, CERAMIDE AP, HYALURONIC ACID(0.0025PPM), COPPER TRIPEPTIDE-1, SODIUM HYALURONATE CROSSPOLYMER(0.001PPM), ACETYL HEXAPEPTIDE-8, PALMITOYL PENTAPEPTIDE-4, HYDROLYZED SODIUM HYALURONATE(0.001PPM), PALMITOYL TETRAPEPTIDE-7, PALMITOYL TRIPEPTIDE-1, POTASSIUM HYALURONATE(0.0002PPM), CERAMIDE EOP
Key features
- Hydrating & Firming with Hyaluronic Acid
- Korean Glass Glow Effect
- Lightweight, Non-Greasy Relief Texture
- Pore Care & Skin Barrier Relief Support
Frequently asked questions
Is the medicube Salmon DNA PDRN Pink Hyaluronic Moisturizing good for sensitive skin?
Yes, it is one of the gentler options in the range and suits most skin types, including sensitive skin. As always, patch test first.
How do you use the medicube Salmon DNA PDRN Pink Hyaluronic Moisturizing?
Use it as the last step of your routine (before sunscreen in the morning). Follow the directions on the pack, and always finish your morning routine with sunscreen.
Is the medicube Salmon DNA PDRN Pink Hyaluronic Moisturizing worth it?
For the price, it is an easy recommendation: 4.6 out of 5 from a large number of shoppers, doing a clear job in the routine. Results vary from person to person, so manage expectations.
Check price on Amazon →