Medicube Exosome Shot Zero 25

Overview

The hero ingredient is exosomes, and you use it as a targeted treatment step. With a strong 4.4 out of 5 from 525 ratings, it is a well-liked pick. It is one of the gentler options in the range, so it suits most skin types including sensitive skin.

The summary above follows how Medicube markets this product. We also read the published ingredient list line by line, and it tells a different story: what the ingredient order actually says.

At a glance

How the ratings break down

Amazon's own star distribution for this product, read on 2026-10-28. We show the one-star share too, because an average alone hides it.

7% of these ratings are one or two stars. That is about typical for the Medicube range, where the median is 6%.

We cannot tell you what those reviewers said. Amazon.com now requires an account to open the full review list, so the critical reviews are not readable from a public page. We would rather say that than guess.

What are exosomes?

Exosomes are cell-signaling particles used in skincare to support a more intensive, treatment-style boost to skin recovery and glow.

Ingredients, as listed by Medicube

Taken from Medicube's own product page on 2026-10-18. We have not verified it against a physical pack, and formulations change by market and batch. If an ingredient matters to you, check the pack itself.

Show the full ingredient list (42 ingredients)

Water, Glycereth-26, Dipropylene Glycol, Butylene Glycol, Caprylic/Capric Triglyceride, Niacinamide, Calcium aluminum borosilicate, Hydrolyzed Sponge, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, 1,2-Hexanediol, Caprylyl Glycol, Isohexadecane, Glycerin, Polysorbate 80, Carbomer, Tromethamine, Panthenol, Ethylhexylglycerin, Adenosine, Sorbitan Oleate, Sorbitan Isostearate, Polysorbate 60, Disodium EDTA, Lactobacillus Extracellular Vesicles(154 ppm), Kummerowia Striata Extract, Oenothera Biennis (Evening Primrose) Flower Extract, Ulmus Davidiana Root Extract, Pinus Palustris Leaf Extract, Pueraria Lobata Root Extract, Cinchona Pubescens Bark Extract, Gluconolactone, Betaine Salicylate, Citric Acid, Milk Exosomes(10 ppm), Leptospermum Scoparium Leaf Extract, Hydrogenated Lecithin, Polyglyceryl-10 Laurate, Ceramide NP, Acetyl Tetrapeptide-5, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5

What the ingredient order actually tells you

• The spicules are high on the list: hydrolyzed sponge sits eighth of 42, behind niacinamide at sixth and a mineral silicate at seventh. Sponge spicules are tiny silica needles, and they produce the tingling the listing tells you is normal.
• The exosomes are declared, which is unusual and useful. Lactobacillus extracellular vesicles sit 25th at 154 ppm and milk exosomes 35th at 10 ppm, that is 0.0154% and 0.001%. The list does not say what the 25,000 PPM in the product name measures, and neither entry matches it.
• A mild acid layer sits in the 30s: gluconolactone 32nd and betaine salicylate 33rd. Three peptides close the list at 40th to 42nd, with ceramide NP at 39th.
• No fragrance entry appears, which helps in a product that already stings by design.

Our read

A spicule booster first and an exosome product second: the sponge needles at eighth define how it feels and what it does, and the exosome entries are present at small declared strengths. Used once a week as the listing suggests, on skin that is not already irritated, it is a texture treatment for oily skin. Do not combine it with retinoids or strong acids on the same night.

Who should skip this

• Your skin is sensitive or your barrier is compromised. Microneedle-like spicules sit eighth on this list.
• You are buying the 25,000 PPM as an exosome dose. The declared exosome entries are 154 ppm and 10 ppm.
• You already use a retinoid nightly. Spicules on top of a retinoid are a common route to irritation.

A note on how we read that list. Ingredient lists run in descending order of concentration, but only for ingredients above 1%. Below that, the order is up to the manufacturer, so a low position tells you something is present at a low level, not exactly how much. We do not guess at percentages. FDA labeling guide.

What the listing says

Medicube's own description of this product, as published on its Amazon.com listing. It is marketing copy, not our assessment, and we have not verified the claims in it.

• TIKTOK VIRAL - Transform your skin with the Exosome Shot Skin Booster Serum. Featuring a micro-sized, needle-shaped design and enriched with 15M patented Exosome shots, this booster provides targeted care, delivering active ingredients to the skin for a revitalized look.
• More powerful intensive pore care - While using the Zero Exosome Shot Serum, you may experience a slight tingling sensation, which is completely normal. This indicates skin texture improvement and proves the formula is working effectively.
• Exosome-Coated Technology - Harness next-generation skincare with Exosome-coated Spicule and Exosome technology, designed to deliver active ingredients to the skin’s surface effectively. Our advanced formula addresses a range of skin concerns, from pore care to enhancing skin vitality and energy.
• Easy to Integrate into Skincare Routine - Apply our Tingling Ampoule once a week as the first step in your skincare routine. It helps improve skin texture and provides intensive pore care.

Full listing title: medicube Exosome Shot Zero 25,000PPM Spicule Facial Serum For Pores & Sebum

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