Medicube Rosemary PDRN Leave in Conditioner Spray

Overview

The hero ingredient is salmon DNA PDRN, and you use it as a targeted treatment step. With a strong 4.4 out of 5 from 33 ratings, it is a well-liked pick. It is one of the gentler options in the range, so it suits most skin types including sensitive skin.

The summary above follows how Medicube markets this product. We also read the published ingredient list line by line, and it tells a different story: what the ingredient order actually says.

At a glance

How the ratings break down

Amazon's own star distribution for this product, read on 2026-10-28. We show the one-star share too, because an average alone hides it.

5% of these ratings are one or two stars. That is about typical for the Medicube range, where the median is 6%.

We cannot tell you what those reviewers said. Amazon.com now requires an account to open the full review list, so the critical reviews are not readable from a public page. We would rather say that than guess.

What is salmon DNA PDRN?

PDRN (polydeoxyribonucleotide) is a soothing, skin-conditioning ingredient derived from salmon DNA, used to support the barrier and give a plumper, glowier look.

What we can and cannot tell you about this spray

• We have not found this spray, with its ingredient list, in Medicube's own US store, so nothing here is read from an ingredient order.
• What we can compare is its sister product. The Rosemary PDRN conditioner from the same line, whose list we do hold, places rosemary, PDRN and biotin well behind its fragrance. We cannot assume the spray follows the same pattern, but it is how this line has been built so far.
• The listing's measurable promises are detangling, frizz control and heat protection during blow-drying, from a spray you leave in. Those are the things to judge it on; the PDRN, biotin and keratin are surface conditioning at most.
• It is fragranced, with a 'citrus-herbal floral' scent according to the listing.

Our read

A leave-in detangler with heat protection, wrapped in a skincare ingredient story. Judge it on combing, frizz and finish over a couple of weeks. Do not expect biotin or PDRN sprayed on the lengths to make hair grow thicker.

Who should skip this

• You want a scalp treatment. This is sprayed on mid-lengths and ends.
• Fragrance bothers you. The listing describes a citrus-herbal floral scent.
• You need an ingredient list to check for silicones or proteins. We could not find a published one.

What the listing says

Medicube's own description of this product, as published on its Amazon.com listing. It is marketing copy, not our assessment, and we have not verified the claims in it.

• [GLASS HAIR FOR ALL] Do-it-all leave-in conditioner spray for dry, damaged, fine, thick, straight, wavy, curly, and color-treated hair. Detangles, smooths frizz, adds shine, and helps protect strands from heat without weighing hair down.
• [DETANGLES HAIR IN SECONDS] Tame stubborn knots and tangles in seconds. This lightweight leave-in conditioner spray helps improve detangling, leaving rough, unruly hair smoother and easier to comb.
• [PDRN + BIOTIN + KERATIN COMPLEX] Powered by PDRN, Biotin, and Keratin, plus a blend of 31 proteins and amino acids, this nourishing formula helps replenish dry, damaged strands and leaves hair feeling stronger, smoother, and healthier-looking.
• [ANTI-FRIZZ & HEAT-PROTECTING PRIMER] The lightweight milky formula coats strands with moisture, smooths frizz and flyaways, and helps protect hair from high-heat blow-drying.
• [SPRAY, DETANGLE & STYLE] After shampooing, spray evenly onto towel-dried hair from 4 - 6 inches away, focusing on the mid-lengths and ends. Comb through, then blow-dry or style as usual - no rinsing needed. Finished with a refreshing citrus-herbal floral scent that settles into soft vanilla and musk.
• [FROM GLASS SKIN TO GLASS HAIR] From the skincare brand known for bestselling PDRN formulas, medicube brings its signature ingredient expertise to hair care - helping fine, dry, damaged strands into smooth, glossy, glass-like hair.

Full listing title: medicube Rosemary PDRN Leave in Conditioner Spray, Do-It-All Detangler

Frequently asked questions

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